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. 2024 Nov 21;30(43):4609–4619. doi: 10.3748/wjg.v30.i43.4609

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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Receiver operating characteristic curve analysis of SHOX2, RNF180, SEPTIN9, and EPO methylation biomarkers. A-D: Receiver operating characteristic (ROC) curves of methylation for squamous cell carcinoma. Area under the curve (AUC)-SHOX2 = 0.639 (95%CI: 0.575–0.703), AUC-SEPTIN9 = 0.731 (95%CI: 0.673–0.789), AUC-EPO = 0.765 (95%CI: 0.710–0.820), and AUC-RNF180 = 0.559 (95%CI: 0.491–0.626); E-H: ROC curve analysis of methylation for adenocarcinoma. AUC-SHOX2 = 0.601 (95%CI: 0.484–0.719), AUC-SEPTIN9 = 0.626 (95%CI: 0.504–0.749), AUC-EPO = 0.691 (95%CI: 0.577–0.805), and AUC-RNF180 = 0.697 (95%CI: 0.582–0.813). ROC: Receiver operating characteristic.