Table 1.
Clinical and magnetic resonance imaging characteristics of participants with pediatric multiple sclerosis.
| Characteristic | Value |
|---|---|
| Patients, No. | 22 |
| Age, median (IQR), years | 16.4 (13.0; 17.4) |
| Girls (%) | 19 (86) |
| Disease duration, median (IQR), years | 0.7 (0.4; 1.3) |
| Patients with oligoclonal bands (% of cases with CSF) | 22 (100) |
| EDSS, median (IQR) | 1.0 (1.0; 2.0) |
| Patients in DMTs (%) | 16 (73) |
| Total number of brain WMLs, No. | 1564 |
| Total number of brain WMLs per patient, median (IQR) | 43 (16; 85) |
| Total number of excluded brain WMLs (confluent WMLs or with multiple veins), No. | 250 |
| Total number of excluded brain WMLs (confluent WMLs or with multiple veins) per patient, median (IQR) | 6.5 (2; 19) |
| Total number of evaluable brain WMLs, No. | 1225 |
| Total number of evaluable brain WMLs per patient, median (IQR) | 30 (13; 71) |
| Total brain CVS+ WMLs, No. | 495 |
| Total brain CVS+ WMLs per patient, median (IQR) | 12 (4; 23) |
| Number of periventricular CVS+ WMLs per patient, median (IQR) | 4 (0; 6) |
| Number of juxtacortical CVS+ WMLs per patient, median (IQR) | 4 (0; 6) |
| Number of infratentorial CVS+ WMLs per patient, median (IQR) | 0 (0; 2) |
| Number of deep CVS+ WMLs per patient, median (IQR) | 4 (1; 10) |
| Total brain PRL+ WMLs, No. | 35 |
| Total brain PRL+ WMLs per patient, median (IQR) | 1 (0; 2) |
| Number of patients with | |
| ≥1 brain CVS+ WML (%) | 21 (95) |
| ≥3 brain CVS+ WMLs (%) | 19 (86) |
| ≥6 brain CVS+ WMLs (%) | 15 (68) |
| Proportion of CVS+ WMLs per patient (%), median (IQR) | 39 (33; 48) |
| Number of patients fulfilling CVS+ threshold | |
| ≥35% (%) | 14 (64) |
| ≥40% (%) | 11 (50) |
| ≥50% (%) | 5 (23) |
| Number of patients with | |
| ≥1 brain PRL (%) | 14 (64) |
| ≥1 brain CVS+ WML or ≥1 PRL (%) | 21 (95) |
| ≥3 brain CVS+ WML or ≥1 PRL (%) | 19 (86) |
| ≥6 brain CVS+ WML or ≥1 PRL (%) | 17 (77) |
CSF, cerebrospinal fluid; CVS, central vein sign; DMT, disease‐modifying treatment; EDSS, Expanded Disability Status Scale; IQR, interquartile range; MRI, magnetic resonance imaging; PRL, paramagnetic rim lesions; WMLs, white matter lesions.