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. 2024 Aug 14;110(11):6941–6952. doi: 10.1097/JS9.0000000000002021

Figure 1.

Figure 1

Mice were subjected or not to 8 h of wet-cage stress and were administered with CpG-C or vehicle 2 h after the onset of stress. Plasma IL-12 was assessed at the end of stress. CpG-C elevated IL-12 levels in both experiments (A, n=30, n=4–7 per group, P=0.0002; B, n=44, n=6–8 per group, P=0.011), and hypothermic wet-cage (HWC) stress abolished the CpG-C-induced increase in IL-12 (A, n=30, P<0.0001; B, n=44, P<0.0001). Boxes represent the second and third quartiles, and whiskers show min and max values.