Table A3.
Mixed-effects regression results to test mean difference for men
| (1) |
(2) |
(3) |
(4) |
|
|---|---|---|---|---|
| CK | AST | ALT | CR | |
| Time = 2 | 1,101.95 (705.74) | 27.02 (30.56) | 10.39 (29.97) | −0.53 (0.05)*** |
| Time = 3 | 1,894.56 (700.13)** | 37.10 (30.33) | 9.51 (29.75) | −0.66 (0.05)*** |
| Time = 4 | 2,443.57 (695.10)*** | 105.06 (30.35)*** | 70.16 (29.76)* | −0.74 (0.05)*** |
| Time = 5 | 2,124.38 (699.71)** | 158.90 (30.09)*** | 130.26 (29.51)*** | −0.80 (0.05)*** |
| Time = 6 | 2,495.85 (753.63)*** | 211.97 (32.21)*** | 207.73 (31.58)*** | −0.85 (0.05)*** |
| Constant | 693.12 (796.88) | 4.97 (27.38) | −36.28 (24.34) | 0.57 (0.06)*** |
| Observations | 243 | 249 | 249 | 252 |
| AIC | 4,656 | 3,217 | 3,191 | 120 |
Mixed-effects models calculated using restricted maximum likelihood with the Kenward–Roger method. Standard errors in parentheses. AIC, Akaike information criterion; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CK, creatine kinase; CR, creatinine. *P < 0.05, **P < 0.01, ***P < 0.001.