. 2024 Nov 5;12:1496111. doi: 10.3389/fbioe.2024.1496111

TABLE 1.

Kinetics parameters of protein released from microparticles for 28 days.

Model	Equation	Parameters	HSA-alone	IL-4 N1	IL-4 N2	HSA N1	HSA N2
Zero order	Q = K₀t + Q₀	K₀	0.787	0.005	0.004	0.474	0.341
		Q₀	14.417	0.102	0.237	19.452	26.381
		R²	0.969	0.627	0.418	0.741	0.729
First order	Q = 1 – e ^−K ₁ ^t	K₁	0.237	0.574	0.794	0.825	0.963
First order	Q = 1 – e ^−K ₁ ^t	R²	0.649	0.992	0.971	0.837	0.717
Higuchi	Q = K_Ht^1/2	K_H	7.175	0.052	0.082	7.700	8.649
Higuchi	Q = K_Ht^1/2	R²	0.751	0.229	−2.605	−1.678	−6.468
Ritger-Peppas	Q = Ktⁿ	K	11.689	0.096	0.210	17.741	23.930
Ritger-Peppas	Q = Ktⁿ	R²	0.957	0.877	0.754	0.950	0.941

Q is the cumulative amount of drug released at time t; K₀, K₁, K_H, and K are regarded as kinetic constant for zero-order release, first-order release, Higuchi, and Ritger-Peppas, respectively. And n is the diffusional exponent denoting the drug transport mechanism.