Table 2.
Performance of ECog-12 to differentiate cognitive statuses
| ECog-12 status | CI vs CU AUC (95%CI) | MCI vs CU AUC (95%CI) | dementia vs MCI AUC (95%CI) | CI with amyloid pathology vs others (CU&CI without amyloid pathology) AUC (95%CI) |
|---|---|---|---|---|
| Average ECog-12 | ||||
| ECog-12 of pt* | CP ≥ 1.36 AUC = 0.7 (0.68-0.73) | CP ≥ 1.37 AUC = 0.7 (0.67-0.72) | CP ≥ 1.7 AUC = 0.57 (0.53-0.61) | CP ≥ 1.36 AUC = 0.65 (0.63-0.68) |
| Ecog-12 of sp* | CP ≥ 1.45 AUC = 0.78 (0.76–0.8) | CP ≥ 1.27 AUC = 0.75 (0.72–0.77) | CP ≥ 1.9 AUC = 0.77 (0.74–0.8) | CP ≥ 1.45 AUC = 0.75 (0.73–0.78) |
| ECog-12 of pt with memory concern ** | AUC = 0.79 (0.77–0.82) | AUC = 0.8 (0.77–0.82) | AUC = 0.49 (0.46–0.53) | AUC = 0.71 (0.69–0.73) |
| Categorized ECog-12 | ||||
| Any consistent SCD categorization of ECog-12 for pt response | AUC = 0.69 (0.67–0.71) | AUC = 0.68 (0.67–0.71) | AUC = 0.53 (0.49-0.56) | AUC = 0.65 (0.62–0.67) |
| Any consistent SCD” group ECog-12 for pt with positive memory concern complaint vs others*** | AUC = 0.73 (0.7–0.75) | AUC = 0.72 (0.67–0.75) | AUC = 0.51 (0.48-0.55) | AUC = 0.68 (0.66–0.71) |
| Any consistent SCD Ecog-12 of pt + concern vs none of both | AUC = 0.79 (0.77–0.82) | AUC = 0.8 (0.77–0.82) | AUC =0.49 (0.46-0.51) | AUC = 0.71 (0.69–0.74) |
| Any consistent SCD categorization of ECog-12 for sp response | AUC = 0.78 (0.76–0.8) | AUC = 0.74 (0.71–0.76) | AUC = 0.66 (0.64-0.68) | AUC = 0.74 (0.72–0.76) |
CP, cutpoint; AUC, Area Under the Curve of the “Receiver Operating Characteristic” curve; pt, self-participant; sp, study partner; CI’ cognitive impaired participants; CU, cognitively unimpaired participants; * Dichotomous score on each cutpoint; ** Performance of ECog-12 combined with positive concern question compared with none of high ECog and memory concern; ***AUC derived from the performance of participants who had any consistent SCD ECog-12 score and positive memory concern complaint compared to those without any consistent SCD in ECog12 and memory concern complaint, as well as those with positive only one of each.