Table 3.

Association between ECog-12 and cognitive impairment (MCI and AD)

Variables	Univariate analysis		Multivariable analysis (model 1*)		Multivariable analysis (model 2**)
	Crude OR (95%CI)	P value	Adjusted OR (95%CI)	P value	Adjusted OR (95%CI)	P value
Average ECog-12 of participants	10 (7.4–13.76)	<0.001	8.79 (6.32–12.43)	<0.001
Average ECog-12 of study partner	38.01 (25.12–59.18)	<0.001			35.45 (22.41–58.03)	< 0.001
Age	1.02 (1.01–1.04)	<0.001	1.01 (0.99–1.03)	0.44	0.99 (0.97–1.01)	0.22
Male gender	1.91 (1.56–2.34)	<0.001	2.05 (1.58–2.67)	<0.001	1.71 (1.28–2.28)	0.003
Education	0.95 (0.87–0.94)	<0.001	0.88 (0.83–0.92)	<0.001	0.94 (0.88–0.99)	0.02
Race (white)	1.99 (1.45–2.65)	<0.001	1.5 (0.97–2.34)	0.07	1.18 (0.74–1.91)	0.49
Married	1.62 (1.29–2.03)	<0.001	1.37(1.02–1.84)	0.04	0.82 (0.59–1.13)	0.23
APOE4 positive	2.16 (1.8–2.6)	<0.001	2.07 (1.69–2.56)	<0.001	1.69 (1.34–2.13)	<0.001
AUC			0.795		0.87

*Model1: association of average ECog-12 score from self-participants and cognitive impairment adjusted with age, gender, educational years, race, marital status, and APOE4 status; **Model2: association of average ECog-12 score from study partners and cognitive impairment adjusted with age, gender, educational years, race, marital status, and APOE4 status