Table 2.

Correlation Between Plasma LBP Levels and the Frequency of TLR⁺ T Cell Subsets from RRMS Patients

	LBP (µg/mL) x % TLR+ T cells
	% TLR2+		% TLR4+
	r	p	r	p
CD4+ T cells
t0	0.3381	0.1844	0.3933	0.1064
t1	0.2990	0.2415	0.4272	0.1996
CD8+ T cells
t0	0.3481	0. 1710	0.3166	0.2006
t1	0. 33,385	0.1895	0.3851	0.1145
	MFI of TLR2		MFI of TLR4
	r	p	r	p
CD4+ T cells
t0	0.5751	0.0125	0.6791	0.0019
t1	0.3318	0.1786	0.5320	0.0231
CD8+ T cells
t0	0.5289	0.0240	0.5527	0.0174
t1	0.4349	0.0713	0.5207	0.0267
	IL-17+ TLR2+		IL-17+TLR4+
	r	p	r	p
CD4+ T cells
t0	0.5460	0.0191	0.7160	0.0009
t1	0.4158	0.0962	0.3558	0.1473
CD8+ T cells
t0	0.6513	0.0034	0.6119	0.0070
t1	0.1354	0.5921	0.3558	0.1473

Note: Plasma LBP levels, quantified just before (t0) and 1 year after (t1) of DMT, were correlated with percentage of TLR-2⁺ and TLR-4⁺ (CD4⁺ and CD8⁺) T cells, MFI of TLR-2 and TLR-4 per (CD4⁺ and CD8⁺) T cells and proportion of IL-17-secreting (CD4⁺ and CD8⁺) T cells positive for TLR-2 and TLR-4 obtained at t0 and t1 from RRMS patients. The Spearman correlation was used to evaluate the correlation between LBP and T cell phenotypes. In bold, the significant values of correlation (p<0.05) are highlighted.