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. 2024 Nov 18;8:265. doi: 10.1038/s41698-024-00729-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — A Somatic alterations identified in breast cancer driver genes in TN-IBC. Gene names and relative frequency of mutations are reported in the double y-axis. Top: bar graph defining the total number of different types of somatic alterations in each patient; bottom: annotation for PmAb treatment, pathologic response, stage at diagnosis, and overall clinical staging. B Altered oncogenic pathways affected by somatic alterations in TN-IBC. C,D Number of somatic variants, including missense, truncating, and inframe variants (C), and CNV load, including copy number gains, losses, and both (D), in TN-IBC and TN-non-IBC. E,F Enrichment of somatic alterations in breast-cancer-associated genes (E) and cancer hallmark genes (F) in TN-IBC compared to TN-non-IBC. *P < 0.05; **P < 0.01; ***P < 0.001; NS, not significant. In C and D, the center line represents the median of the data. The edges of the box correspond to the 75th percentile and the 25th percentile respectively, showing the interquartile range (IQR). The whiskers extend to the largest and smallest values within 1.5 times the IQR from the 25th and 75th percentiles. Outliers, defined as data points beyond the whiskers, are plotted individually as dots.