Fig. 6. Investigation of the in vivo therapeutic effect of TBmA-Glu mediated phototherapy.
a The fluorescence images represent mice in TBmA-Glu and TBmA PDT treatment groups at the start and end of the treatment process. The white circles indicate the region of tumors. TBmA-Glu and TBmA, λex = 500 nm, λem = 700 nm (Long-pass filter). b Tumor growth curves of tumor-bearing mice (n = 5), data expressed as average ± standard error. The red arrows indicate the time points for drug administration. c The H&E (upper panel) and immunohistochemistry of GPX4 (lower panel) in tumor sections from mice in TBmA-Glu treatment groups. Three independent experiments were performed. Scale bars: 50 μm.