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. 2024 Nov 19;8:268. doi: 10.1038/s41698-024-00739-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — Plots illustrating DLL3 gene (a) and protein (c) expression patterns of small cell lung carcinoma (SCLC), large cell neuroendocrine carcinoma (LCNEC), non-small cell lung carcinoma (NSCLC) and showing higher levels of DLL3 gene (b) and protein (d) expression in SCLC and LCNEC cell lines compared to NSCLC. Illustrate higher levels of intracellular/cytoplasmic DLL3 compared to cell surface/membrane location, evaluated by flow cytometry (e) and immunohistochemistry (f). Lung cancer cell lines with known DLL3 expression by IHC. g, h Microphotographs showing different levels of DLL3 IHC expression (negative in H460, moderate in H82 and high in SHP77) (g). Correlation graphs and Total-Scores, Membrane H-Score, and Cytoplasmic S-core. Panels contains Spearman’s correlation coefficient and P values (h).