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. 2024 Nov 19;8:268. doi: 10.1038/s41698-024-00739-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — Left side: low magnification microphotograph of combined tumor stained with H&E (×4). a Miniatures showing higher magnification of the large cell neuroendocrine carcinoma pattern (b) and adenocarcinoma acinar pattern (×40). c Low magnification of the same tumor stained with DLL3 (4X). d Miniatures of the same areas (b, c) showing large cell neuroendocrine carcinoma expressing DLL3 (e), and adenocarcinoma without DLL3 expression (×40) (f). Right side: Microphotograph at medium magnification (×10) of another combined tumor stained with H&E (g). Miniatures showing higher magnification of the large cell neuroendocrine carcinoma pattern (h) and adenocarcinoma solid pattern (i) (×40). Same area stained with DLL3 (j) (10X). Miniatures at higher magnification showing large cell neuroendocrine carcinoma expressing DLL3 (l) and adenocarcinoma without DLL3 expression (k) (×40).