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. 2024 Nov 18;15:9885. doi: 10.1038/s41467-024-53663-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Whole mount in situ hybridization (WISH) of 3 dpf AB zebrafish shows Abcb6 expression in the inner ear when treated with a zebrafish abcb6 anti-sense mRNA probe (i-iii). The auditory vesicle is denoted with black arrows. Zebrafish Abcb6 expression is not detected with a zebrafish abcb6 sense mRNA probe (iv). b Zebrafish Abcb6 MO15 morphants (purple) developed a reduced number of hair cells compared to WT (indigo) in zebrafish neuromasts. Data were analyzed by 2-way ANOVA with genotype and neuromast as factors. There is a significant main effect of genotype (F_1,111 = 126.6, p < 0.0001) and neuromast (F_6,111 = 6.13, p < 0.0001). O1, O2, and MI2 neuromasts are found on the head, P1 and P2 represent the first two neuromasts of the posterior lateral line (trunk), and T1 and T2 are the two terminal-most neuromasts on the tail (neuromast nomenclature modified from Raible and Kruse, 2000)⁹⁰. Hair cell counts are from 3 dpf brn3c transgenic larvae, N = 8 fish for uninjected, N = 9 fish for Abcb6 MO15, bars represent mean + 1 SEM. The person counting hair cells was blinded to treatment. Experiment was repeated and the results showed the same pattern. Source data from (b) are provided in the Source Data file.