TABLE 6.

Diagnostic values of Mex3a methylation level, Mex3a mRNA level, and the combined determination with AFP for distinguishing HBV-associated HCC from CHB.

Parameter	Sensitivity	Specificity	Youden index	AUC	95% CI	p-value compared to AFP
Mex3a mRNA level	63.8	93.6	0.574	0.806	0.767–0.844	0.0021
Mex3a PMR	87.8	62.5	0.503	0.777	0.740–0.813	0.0327
AFP	51.5	74.0	0.555	0.715	0.672–0.757	—
Mex3a mRNA level + AFP	72.5	93.1	0.656	0.845	0.810–0.880	<0.0001
Mex3a PMR + AFP	90.4	63.0	0.533	0.836	0.805–0.868	<0.0001
Mex3a mRNA level + Mex3a PMR + AFP	75.1	91.3	0.664	0.915	0.892–0.937	<0.0001