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. 2024 Aug 16;2(11):776–785. doi: 10.1021/envhealth.4c00098

Figure 5.

Figure 5

Dependency of F-53B-declined synaptic proteins levels in HT22 neurons on the PKA/CREB pathway. (A) The survival rate of HT22 neurons treated with a PKA agonist and antagonist. (B) The relative mRNA levels of PKA in HT22 neurons treated with a PKA agonist and antagonist. (C) The survival rate of HT22 neurons treated with both a PKA agonist or antagonist and F-53B. (D-F) The nuclear protein blots and diagrams of the PKA/CREB pathways in HT22 neurons treated with both a PKA agonist or antagonist and F-53B. (G-J) The total protein blots and diagrams of the synaptic plasticity in HT22 neurons treated with both a PKA agonist or antagonist and F-53B. The “*” indicates a significant difference compared to the groups without F-53B, PKA agonist, and PKA antagonist. “*” and “&” indicate p < 0.05, “**” and “&&” indicate p < 0.01, “***” and “&&&” indicate p < 0.001.