All the variables are measured at baseline unless indicated otherwise. Univariate analyses for baseline variables with an unadjusted P value of less than .05. Apolipoprotein E (APOE) ε4, dyslipidemia, sex, diabetes, and presence of amyloid-related imaging abnormalities-hemosiderin are treated as categorical variables with associated reference levels of APOE ε4 noncarrier, no dyslipidemia, female, no diabetes, and absent. Aβ indicates amyloid-beta; CSF, cerebrospinal fluid; HR, hazard ratio; LT, log 2 transformed; MRI, magnetic resonance imaging; OR, odds ratio; PET, positron emission tomography; SS, superficial siderosis.