Figure 3. Multivariate Modeling With Stepwise Logistic Regression for Baseline Variables.

Apolipoprotein E (APOE) ε4 and sex are treated as categorical variables with APOE ε4 noncarrier and female as the reference levels. In addition to those meeting criteria for univariate significance, hippocampal volume, whole-brain volume, systolic blood pressure, and sex were retained in multivariate models of amyloid-related imaging abnormalities-edema risk. In models containing cerebrospinal fluid (CSF) measures, CSF pTau, CSF tTau, and weight were also retained; whereas in amyloid positron emission tomography (PET) models, amyloid PET centiloid, and total number of amyloid-related imaging abnormalities-hemosiderin remained in multivariate models. OR indicates odds ratio.

^aPer 1 mm Hg; per 10 mm Hg, the OR would be 1.1.