Figure 7.

LPS induces human ILC2-mediated eosinophilic lung inflammation in humanized mouse models

(A) An experimental protocol for studying the activation of human ILC2s by LPS in two humanized mouse models.

(B) FACS showing the number of human ILC2s in the lungs of NSG or Rag2^−/−γc^−/− mice, which were reconstituted with human ILC2s and treated with or without LPS.

(C) As in B, the percentage of IL5⁺IL13⁺-double positive human ILC2s in NSG or Rag2^−/−γc^−/− mice was analyzed by intracellular staining.

(D) As in B, FACS showing the number of lung eosinophils in NSG or Rag2^−/−γc^−/− mice (unpaired t-test, ∗∗p < 0.01, ∗∗∗p < 0.001).