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. 2024 Nov 18;156(12):e202413584. doi: 10.1085/jgp.202413584

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© 2024 Davies et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 8. — Structural model of VcGluQM and the predicted interactions with VcGluP. (A) Side view and top-down view of the structural model of VcGluQM generated by Alphafold2. The transport or “elevator” domain is colored orange, the scaffold (including the “Q” domain) is blue, and the claw domain is colored light purple. (B) Side view and top-down view of the cryo-EM structure of HiSiaQM (PDB ID: 7QE5), colored the same as for VcGluQM in A. (C) Topology maps of HiSiaQM and VcGluQM based on the cryo-EM structure and AlphaFold2 prediction, respectively. Maps colored as in A. (D) Superimposition of the chain traces of the transport domains of VcGluQM (orange) and HiSiaQM (pink). (E) Cartoon representation of the Colabfold model of the holocomplex VcGluPQM, colored as in A and with VcGluP colored red. VcGluQM and VcGluPQM Colabfold Models colored by pLDDT are presented in Fig. S4.