Table 1.
List of the 100 most-cited articles in hypothermic brain protection journals.
| Ranking | Title | JCR® IF | Total citations | Average citation | Journal | First author | Corresponding author | Published year |
|---|---|---|---|---|---|---|---|---|
| 1 | Glutamate release and free-radical production following brain injury—effects of posttraumatic hypothermia | 4.7 | 470 | 16.8 | Journal of Neurochemistry | Globus, MYT | Globus, MYT | 1995 |
| 2 | Marked protection by moderate hypothermia after experimental traumatic brain injury | 6.3 | 440 | 13.8 | Journal of Cerebral Blood Flow and Metabolism | Clifton, GL | Dr. G. L. Clifton | 1991 |
| 3 | Delay in cooling negates the beneficial effect of mild resuscitative cerebral hypothermia after cardiac-arrest in dogs— a prospective, randomized study | 8.8 | 417 | 13.9 | Critical Care Medicine | Kuboyama, K | Peter Safar | 1993 |
| 4 | Therapeutic modulation of brain temperature—relevance to ischemic brain injury | 6.9 | 416 | 13.4 | Cerebrovascular and Brain Metabolism Reviews | Ginsberg, MD | Ginsberg, MD | 1992 |
| 5 | Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats | 6.3 | 410 | 13.7 | Journal of Cerebral Blood Flow and Metabolism | Dietrich, WD | Dietrich, WD | 1993 |
| 6 | Delayed postischemic hypothermia—a 6 month survival study using behavioral and histological assessments of neuroprotection | 5.3 | 409 | 14.6 | Journal of Neuroscience | Colbourne, F | Frederick Colbourne | 1995 |
| 7 | Mild intraoperative hypothermia during surgery for intracranial aneurysm | 158.5 | 345 | 19.2 | New England Journal of Medicine | Todd, MM | Todd, MM | 2005 |
| 8 | Effects of hypothermia on energy metabolism in mammalian central nervous system | 6.3 | 328 | 16.4 | Journal of Cerebral Blood Flow and Metabolism | Erecinska, M | Erecinska, M | 2003 |
| 9 | Protective effects of moderate hypothermia after neonatal hypoxia-ischemia: short-and long-term outcome | 3.6 | 273 | 10.9 | Pediatric Research | Bona, E | Thoresen, M | 1998 |
| 10 | Posttraumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat | 12.7 | 271 | 9.3 | Acta Neuropathologica | Dietrich, WD | Dietrich, WD | 1994 |
| 11 | The effect of hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral metabolism in neonates, infants, and children | 6 | 258 | 8.1 | Journal of Thoracic and Cardiovascular Surgery | Greeley, WJ | Greeley, WJ | 1991 |
| 12 | Brain temperature alters hydroxyl radical production during cerebral ischemia reperfusion in rats | 6.3 | 248 | 9.2 | Journal of Cerebral Blood Flow and Metabolism | Kil, HY | Dr. C. A. Piantadosi | 1996 |
| 13 | Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse | 3.5 | 237 | 8.2 | Journal of Pharmacology and Experimental Therapeutics | Miller, DB | Miller, DB | 1994 |
| 14 | Induced hypothermia in critical care medicine: a review | 8.8 | 233 | 11.7 | Critical Care Medicine | Bernard, SA | Bernard, SA | 2003 |
| 15 | Antegrade cerebral perfusion with cold blood: a 13-year experience | 4.6 | 228 | 9.5 | Annals of Thoracic Surgery | Bachet, J | Bachet, J | 1999 |
| 16 | Treatment advances in neonatal neuroprotection and neurointensive care | 48 | 219 | 18.3 | Lancet Neurology | Johnston, Michael V | Johnston, MV | 2011 |
| 17 | The relationship among canine brain temperature, metabolism, and function during hypothermia | 8.8 | 213 | 6.7 | Anesthesiology | Michenfelder, JD | Michenfelder, JD | 1991 |
| 18 | Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia | 11.2 | 213 | 11.8 | Annals of Neurology | Ma, DQ | Maze, M | 2005 |
| 19 | Low environmental temperatures or pharmacological agents that produce hypothermia decrease methamphetamine neurotoxicity in mice | 2.9 | 185 | 6.4 | Brain Research | Ali, SF | Ali, SF | 1994 |
| 20 | Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants | 8 | 180 | 8.6 | Pediatrics | Shankaran, S | Shankaran, S | 2002 |
| 21 | Moderate hypothermia mitigates neuronal damage in the rat-brain when initiated several hours following transient cerebral-ischemia | 12.7 | 177 | 6.1 | Acta Neuropathologica | Coimbra, C | C. Coimbra | 1994 |
| 22 | Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade | 6.3 | 176 | 8.4 | Journal of Cerebral Blood Flow and Metabolism | Xu, LJ | Giffard, RG | 2002 |
| 23 | Long-lasting neuroprotective effect of postischemic hypothermia and treatment with an anti-inflammatory/antipyretic drug—evidence for chronic encephalopathic processes following ischemia | 8.3 | 176 | 6.5 | Stroke | Coimbra, C | Coimbra, C | 1996 |
| 24 | Posthypoxic cooling of neonatal rats provides protection against brain injury | 4.4 | 174 | 6.4 | Archives of Disease in Childhood-fetal and Neonatal Edition | Thoresen, M | Dr. Marianne Thoresen | 1996 |
| 25 | Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia | 8.3 | 174 | 11.6 | Stroke | Hobbs, Catherine | Thoresen, M | 2008 |
| 26 | Chronic histopathological consequences of fluid-percussion brain injury in rats: effects of post-traumatic hypothermia | 12.7 | 169 | 6.5 | Acta Neuropathologica | Bramlett, HM | Bramlett, HM | 1997 |
| 27 | Effect of hypothermia on cerebral blood flow and metabolism in the pig | 4.6 | 168 | 8.0 | Annals of Thoracic Surgery | Ehrlich, MP | Griepp, RB | 2002 |
| 28 | Indefatigable ca1 sector neuroprotection with mild hypothermia induced 6 h after severe forebrain ischemia in rats | 6.3 | 163 | 6.8 | Journal of Cerebral Blood Flow and Metabolism | Colbourne, F | Colbourne, F | 1999 |
| 29 | Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy | 4.9 | 161 | 14.6 | Archives of Disease in Childhood-Fetal and Neonatal Edition | Shankaran, Seetha | Shankaran, S | 2012 |
| 30 | Protective effects of brain hypothermia on behavior and histopathology following global cerebral-ischemia in rats | 2.9 | 158 | 5.1 | Brain Research | Green, EJ | Green, EJ | 1992 |
| 31 | RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration | 64.8 | 155 | 19.4 | Nature | Peretti, Diego | Mallucci, GR | 2015 |
| 32 | Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits | 8.3 | 152 | 4.8 | Stroke | Baker, AJ | Dr. M. H. Zornow | 1991 |
| 33 | Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation | 5.3 | 148 | 7.0 | Journal of Neuroscience | Han, HS | Yenari, MA | 2002 |
| 34 | Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation | 8.3 | 146 | 7.3 | Stroke | Deng, H | Yenari, MA | 2003 |
| 35 | General versus specific actions of mild-moderate hypothermia in attenuating cerebral ischemic damage | 6.3 | 145 | 9.1 | Journal of Cerebral Blood Flow and Metabolism | Zhao, Heng | Zhao, H | 2007 |
| 36 | The importance of brain temperature in cerebral injury | 4.2 | 143 | 4.6 | Journal of Neurotrauma | Dietrich, WD | Dietrich, WD | 1992 |
| 37 | Protection against hippocampal ca1 cell loss by postischemic hypothermia is dependent on delay of initiation and duration | 3.6 | 142 | 4.6 | Metabolic Brain Disease | Carroll, M | Carroll, M | 1992 |
| 38 | Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat | 3.5 | 142 | 5.3 | Journal of Pharmacology and Experimental Therapeutics | Malberg, JE | Karen Sabol | 1996 |
| 39 | Twenty-four hours of mild hypothermia in unsedated newborn pigs starting after a severe global hypoxic-ischemic insult is not neuroprotective | 3.6 | 138 | 6.3 | Pediatric Research | Thoresen, M | Thoresen, M | 2001 |
| 40 | Posttraumatic brain hypothermia provides protection from sensorimotor and cognitive-behavioral deficits | 4.2 | 135 | 4.8 | Journal of Neurotrauma | Bramlett, HM | Edward J. Green | 1995 |
| 41 | Hypothermia for acute brain injury-mechanisms and practical aspects | 38.1 | 134 | 12.2 | Nature Reviews Neurology | Choi, H. Alex | Mayer, SA | 2012 |
| 42 | Hypothermia as a potential treatment for cerebral-ischemia | 131 | 4.4 | Cerebrovascular and Brain Metabolism Reviews | Maher, J | 1993 | ||
| 43 | Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood-brain barrier damage and brain oedema independently of infarct size | 9.3 | 130 | 10.8 | Journal Of Neuroinflammation | Denes, Adam | Denes, A | 2011 |
| 44 | Hibernation in ground squirrels induces state and species-specific tolerance to hypoxia and aglycemia: an in vitro study in hippocampal slices | 6.3 | 128 | 5.1 | Journal of Cerebral Blood Flow and Metabolism | Frerichs, KU | Frerichs, KU | 1998 |
| 45 | Hypothermia in the management of traumatic brain injury—a systematic review and meta-analysis | 38.9 | 127 | 6.4 | Intensive Care Medicine | Henderson, WR | Henderson, WR | 2003 |
| 46 | Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia | 4.2 | 125 | 8.9 | Journal of Neurotrauma | Dietrich, W. Dalton | Dietrich, WD | 2009 |
| 47 | A comfortable hypothesis reevaluated—cerebral metabolic depression and brain protection during ischemia | 8.8 | 125 | 4.0 | Anesthesiology | Todd, MM | Todd, MM | 1992 |
| 48 | Delayed induction of mild hypothermia to reduce infarct volume after temporary middle cerebral-artery occlusion in rats | 4.1 | 125 | 4.3 | Journal of Neurosurgery | Karibe, H | Philip R. Weinstein | 1994 |
| 49 | Neuroprotection after several days of mild, drug-induced hypothermia | 6.3 | 124 | 4.6 | Journal of Cerebral Blood Flow and Metabolism | Nurse, S | Nurse, S | 1996 |
| 50 | Selective antegrade cerebral perfusion and mild (28°C–30°C) systemic hypothermic circulatory arrest for aortic arch replacement: results from 1002 patients | 6 | 124 | 11.3 | Journal of Thoracic and Cardiovascular Surgery | Zierer, Andreas | Zierer, A | 2012 |
| 51 | Effects of isoflurane and hypothermia on glutamate receptor-mediated calcium influx in brain-slices | 8.8 | 123 | 4.2 | Anesthesiology | Bickler, PE | Bickler, PE | 1994 |
| 52 | Cirp protects against tumor necrosis factor-alpha-induced apoptosis via activation of extracellular signal-regulated kinase | 5.1 | 123 | 7.2 | Biochimica et Biophysica Acta-Molecular Cell Research | Sakurai, Toshiharu | Fujita, J | 2006 |
| 53 | Neuroprotective adaptations in hibernation: therapeutic implications for ischemia-reperfusion, traumatic brain injury and neurodegenerative diseases | 7.4 | 122 | 5.5 | Free Radical Biology and Medicine | Drew, KL | Drew, KL | 2001 |
| 54 | A comparison of the cerebral protective effects of isoflurane and mild hypothermia in a model of incomplete forebrain ischemia in the rat | 8.8 | 122 | 3.9 | Anesthesiology | Sano, T | Drummond | 1992 |
| 55 | Therapeutic hypothermia: neuroprotective mechanisms | 3.1 | 121 | 7.6 | Frontiers in Bioscience-Landmark | Liu, Liping | Yenari, MA | 2007 |
| 56 | Temperature modulation of ischemic neuronal death and inhibition of calcium calmodulin-dependent protein kinase-ii in gerbils | 8.3 | 120 | 3.6 | Stroke | Churn, SB | Robert J. DeLorenzo | 1990 |
| 57 | Resuscitative hypothermia | 8.8 | 119 | 4.4 | Critical Care Medicine | Marion, DW | Marion, DW | 1996 |
| 58 | Mild-to-moderate hypothermia in aortic arch surgery using circulatory arrest: a change of paradigm? | 3.4 | 118 | 10.7 | European Journal of Cardio-Thoracic Surgery | Urbanski, Paul P | Urbanski, PP | 2012 |
| 59 | Persistent neuroprotection with prolonged postischemic hypothermia in adult rats subjected to transient middle cerebral artery occlusion | 5.3 | 118 | 5.1 | Experimental Neurology | Corbett, D | Colbourne, F | 2000 |
| 60 | Metabolic downregulation—a key to successful neuroprotection? | 8.3 | 118 | 7.9 | Stroke | Yenari, Midori | Yenari, M | 2008 |
| 61 | Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia | 6.3 | 118 | 8.4 | Journal of Cerebral Blood Flow and Metabolism | Thoresen, Marianne | Dingley, J | 2009 |
| 62 | Antegrade selective cerebral perfusion in thoracic aorta surgery: safety of moderate hypothermia | 3.1 | 117 | 7.3 | European Journal of Cardio-Thoracic Surgery | Pacini, Davide | Pacini, D | 2007 |
| 63 | Occurrence of potentially detrimental temperature alterations in hospitalized patients at risk for brain injury | 8.9 | 117 | 4.7 | Mayo Clinic Proceedings | Albrecht, RF | Lanier, WL | 1998 |
| 64 | Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB) | 4.2 | 116 | 6.8 | Neurochemistry International | Yenari, Midori A | Yenari, MA | 2006 |
| 65 | Mild posttraumatic hypothermia reduces mortality after severe controlled cortical impact in rats | 6.3 | 115 | 4.3 | Journal of Cerebral Blood Flow and Metabolism | Clark, RSB | P. M. Kochanek | 1996 |
| 66 | Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats | 8.3 | 115 | 6.1 | Stroke | Liu, YQ | Silverstein, FS | 2004 |
| 67 | Low-flow hypothermic cardiopulmonary bypass protects the brain | 6 | 114 | 3.6 | Journal of Thoracic and Cardiovascular Surgery | Swain, JA | Julie Swain | 1991 |
| 68 | Posttraumatic hypothermia in the treatment of axonal damage in an animal model of traumatic axonal injury | 4.1 | 112 | 4.5 | Journal of Neurosurgery | Koizumi, H | Povlishock, JT | 1998 |
| 69 | Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice | 6.1 | 110 | 15.7 | Neurobiology of Disease | Lee, Jin Hwan | Yu, SP | 2016 |
| 70 | Cooling the injured brain: how does moderate hypothermia influence the pathophysiology of traumatic brain injury | 3.1 | 109 | 6.8 | Current Pharmaceutical Design | Sahuquillo, Juan | Sahuquillo, J | 2007 |
| 71 | A study of brain protection during total arch replacement comparing antegrade cerebral perfusion versus hypothermic circulatory arrest, with or without retrograde cerebral perfusion: analysis based on the japan adult cardiovascular surgery database | 6 | 108 | 13.5 | Journal of Thoracic and Cardiovascular Surgery | Okita, Yutaka | Okita, Y | 2015 |
| 72 | Effects of pH on brain energetics after hypothermic circulatory arrest | 4.6 | 107 | 3.6 | Annals of Thoracic Surgery | Aoki, M | Dr. Jonas | 1993 |
| 73 | Postischemic hypothermia and il-10 treatment provide long-lasting neuroprotection of ca1 hippocampus following transient global ischemia in rats | 5.3 | 106 | 4.4 | Experimental Neurology | Dietrich, WD | Dietrich, WD | 1999 |
| 74 | Moderate posttraumatic hypothermia decreases early calpain-mediated proteolysis and concomitant cytoskeletal compromise in traumatic axonal injury | 5.3 | 102 | 4.3 | Experimental Neurology | Buki, A | Buki, A | 1999 |
| 75 | Protective effects of moderate hypothermia on behavioral deficits but not necrotic cavitation following cortical impact injury in the rat | 4.2 | 101 | 4.0 | Journal of Neurotrauma | Dixon, CE | Hayes, RL | 1998 |
| 76 | Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke | 6.3 | 100 | 4.8 | Journal of Cerebral Blood Flow and Metabolism | Yenari, MA | Yenari, MA | 2002 |
| 77 | Moderate hypothermia and unilateral selective antegrade cerebral perfusion: a contemporary cerebral protection strategy for aortic arch surgery | 4.6 | 100 | 7.7 | Annals of Thoracic Surgery | Leshnower, Bradley G | Chen, EP | 2010 |
| 78 | Prolonged mild hypothermia therapy protects the brain against permanent focal ischemia | 8.3 | 98 | 4.5 | STROKE | Yanamoto, H | Yanamoto, H | 2001 |
| 79 | Role of hypothermia in the mechanism of protection against serotonergic toxicity. II. Experiments with methamphetamine, p-chloroamphetamine, fenfluramine, dizocilpine and dextromethorphan | 3.5 | 98 | 3.5 | Journal of Pharmacology and Experimental Therapeutics | Farfel, GM | Lewis Seiden | 1995 |
| 80 | Intracerebral temperature in neurosurgical patients | 4.8 | 98 | 3.1 | Neurosurgery | Mellergard, P | Mellergard, P | 1991 |
| 81 | Therapeutic hypothermia for acute stroke | 48 | 96 | 4.8 | Lancet Neurology | Olsen, TS | Olsen, TS | 2003 |
| 82 | Cerebral oxygen-metabolism during hypothermic circulatory arrest in humans | 4.1 | 96 | 3.2 | Journal of Neurosurgery | Ausman, JI | Ausman, JI | 1993 |
| 83 | Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery | 8.8 | 95 | 4.3 | Anesthesiology | Grigore, AM | Newman, MF | 2001 |
| 84 | Delayed, spontaneous hypothermia reduces neuronal damage after asphyxial cardiac arrest in rats | 8.8 | 95 | 4.1 | Critical Care Medicine | Hickey, RW | Hickey, RW | 2000 |
| 85 | Combination of systemic hypothermia and n-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats | 3.6 | 94 | 5.5 | Pediatric Research | Jatana, M | Jenkins, D | 2006 |
| 86 | Mild intraischemic hypothermia suppresses consumption of endogenous antioxidants after temporary focal ischemia in rats | 2.9 | 94 | 3.2 | Brain Research | Karibe, H | Philip R. Weinstein | 1994 |
| 87 | Therapeutic time window of post-ischemic mild hypothermia and the gene expression associated with the neuroprotection in rat focal cerebral ischemia | 2.9 | 94 | 5.9 | Neuroscience Research | Ohta, Hiroyuki | Shintani, Y | 2007 |
| 88 | Hypothetical pathophysiology of acute encephalopathy and encephalitis related to influenza virus infection and hypothermia therapy | 1.4 | 93 | 4.0 | Pediatrics International | Yokota, S | Yokota, S | 2000 |
| 89 | Effect of delayed MK-801 (dizocilpine) treatment with or without immediate postischemic hypothermia on chronic neuronal survival after global forebrain ischemia in rats | 6.3 | 93 | 3.3 | Journal of Cerebral Blood Flow and Metabolism | Dietrich, WD | Dietrich, WD | 1995 |
| 90 | Mild postischemic hypothermia limits cerebral injury following transient focal ischemia in rat neocortex | 2.9 | 93 | 3.4 | Brain Research | Yanamoto, H | Kevin S. Lee | 1996 |
| 91 | Regional alterations of protein-kinase-c activity following transient cerebral-ischemia—effects of intraischemic brain temperature modulation | 4.7 | 89 | 3.1 | Journal Of Neurochemistry | Busto, R | Busto, R | 1994 |
| 92 | Treatment window for hypothermia in brain injury | 4.1 | 88 | 4.0 | Journal of Neurosurgery | Markgraf, CG | Markgraf, CG | 2001 |
| 93 | Behavioral protection by moderate hypothermia initiated after experimental traumatic brain injury | 4.2 | 88 | 2.9 | Journal of Neurotrauma | Lyeth, BG | Lyeth, BG | 1993 |
| 94 | Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury | 8.3 | 88 | 5.5 | Stroke | Doyle, Kristian P | Stenzel-Poore, MP | 2007 |
| 95 | Mild to moderate hypothermia prevents microvascular basal lamina antigen loss in experimental focal cerebral ischemia | 8.3 | 88 | 4.6 | Stroke | Hamann, GF | Hamann, GF | 2004 |
| 96 | Diminished neuronal damage in the rat brain by late treatment with the antipyretic drug dipyrone or cooling following cerebral ischemia | 12.7 | 88 | 3.3 | Acta Neuropathologica | Coimbra, C | Coimbra, C | 1996 |
| 97 | Therapeutic hypothermia alters microrna responses to traumatic brain injury in rats | 6.3 | 87 | 7.3 | Journal of Cerebral Blood Flow and Metabolism | Truettner, Jessie S | Dietrich, WD | 2011 |
| 98 | Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments using 3,4-methylenedioxymethamphetamine, dizocilpine, CGS 19755 and NBQX | 3.5 | 87 | 3.1 | Journal of Pharmacology and Experimental Therapeutics | Farfel, GM | Lewis Seiden | 1995 |
| 99 | The relationship between intelligence and duration of circulatory arrest with deep hypothermia | 6 | 87 | 3.1 | Journal of Thoracic and Cardiovascular Surgery | Oates, RK | Oates, RK | 1995 |
| 100 | Delayed onset of prolonged hypothermia improves outcome after intracerebral hemorrhage in rats | 6.3 | 86 | 4.5 | Journal of Cerebral Blood Flow and Metabolism | MacLellan, CL | Colbourne, F | 2004 |
JCRIF, Journal Citation Reports Impact Factor; average citations, average number of citations per year since publication.