Fig. 4.

Chiglitazar reversed insulin resistance (IR) and metabolic abnormalities in rats with polycystic ovary syndrome (PCOS). The serum Insulin (A) and adiponectin (B) levels. C HOMA-IR was calculated according to the formula, HOMA-IR = (FBG × insulin level)/22.5 test. D QUICKI was calculated according to the formula, insulin sensitivity index (QUICKI) = 1/[lg(fasting insulin (μU/mL)) + lg(fasting glucose (mg/dL))]. E–G Serum cholesterol (TC), triglyceride (TG), free fatty acid (FFA) concentration in each group. H Atherosclerosis index (AI) was calculated according to the formula, AI = [TC—HDL] ÷ HDL. Serum HDL (I) and LDL (J) concentrations. All of the above were subjected to one-way analysis of variance with Tukey’s post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001. All data are expressed as the mean ± standard error of the mean. HDL, high-density lipoprotein; LDL, low-density lipoprotein