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. 2024 Oct 16;27(11):111137. doi: 10.1016/j.isci.2024.111137

Figure 1.

Figure 1

HIV infection associated with different transcriptional profiles in blood compared to the bronchoalveolar space

(A) Principal-component analyses of whole-genome level bulk transcriptomes, displaying PC1 and PC2, stratified on the left by compartment (blood or bronchoalveolar [BAL]) and on the right by the presence or absence of HIV infection (n = 20, HIV-negative [10] and HIV-positive [10]).

(B) Relative proportions of major immune cell types in blood (left) and BAL (right) compartments per participant (columns), stratified by HIV status.

(C) Whole-genome differential gene expression transcriptional analysis from blood and BAL samples; volcano plots indicate genes with significantly elevated expression (p adjusted <0.05) in HIV infection in blood (red) and BAL (blue) compartments.

(D) Dot plot of genes with elevated expression in blood and BAL compartments of people with HIV. Colors represent genes showing elevated expression only in blood (red), only in BAL (blue), or in both compartments (magenta).