Fig. 12. (A) The schematic illustration of LINNAEUS which utilizes genetic barcodes for constructing the lineage tree of zebrafish line. This figure has been reproduced from Nat Biotechnol, 2018, 36, 469–473, with permission from Springer Nature Publishing, copyright 2018.4 (B) A universal CRISPR array repair lineage tracing (CARLIN) mouse line constructed by the introduction of Cas9-based scar. The mouse line can be applied in phylogeny analysis, clonal tracing and analysis of functional heterogeneity. This figure has been reproduced from Cell, 2020, 181, 1693–1694, with permission from Elsevier, copyright 2020.21.
