Fig. 14. Applications of time-resolved scRNA-seq in studying transcriptional changes of cancer. (A) Schematic illustration of regulon identification through linking TFs with their regulated genes. The heat map presenting the average regulon activity of 3 regulons of HCT116 cells after 5-AZA-CdR treatment. This figure has been reproduced from Nat Methods, 2020, 17, 991–1001, with permission from Springer Nature Publishing, copyright 2023.10 (B) The subtype switching of single GBM brain tumor cells identified by the cytoplasmic biopsy-based time-resolved scRNA-seq. This figure has been reproduced from Sci Adv, 2024, 10, eadl0515, with permission from American Association for the Advancement of Science Publishing, copyright 2024.15.
