MicroRNA in drug resistance with potential targets in breast cancer.

MicroRNA	Expression levels	Resistant drug	Target	Function	Reference
miR-221	Upregulated	Tamoxifen	P27 kip1	Enhances proliferation and invasion	56
miR-155	Upregulated	Doxorubicin	FOXO	Promotes proliferation and reduces apoptosis	57
miR-30b	Upregulated	Trastuzumab	CCNE2	Induces the apoptosis pathway	58
miR-26a	Upregulated	Trastuzumab	CCNE2	Induces the apoptosis pathway	58
miR-21	Upregulated	Trastuzumab	PTEN, PDCD4	Cell survival, apoptosis, resistance to systemic therapy	59
miR-107	Downregulated	Paclitaxel	E2F1	Promotes apoptosis	60
miR-7	Downregulate	Trastuzumab	EGFR	Induces cell proliferation and metastasis	61
miR-128	Upregulated	Letrozole	TGBR1	Growth inhibitory effect of TGFβ	62
miR-214	Downregulated	Tamoxifen	UCP2	Inhibition of autophagy	63
miR-159	Upregulated	Doxorubicin	Wnt	Promotes apoptosis	64
miR-16	Upregulated	Doxorubicin	Bcl-2	Induces tumor cell apoptosis	65
miR-298	Upregulated	Doxorubicin	P-gp	Alters MDR modulation	66
miR-302b	Downregulated	Cisplatin	E2F1	Inhibit cell cycle progression	67
Let-7a	Upregulated	Paclitaxel	ABCB10	Promotes invasion and autophagy	68
miR-375	Downregulated	Trastuzumab	IGF1R	Reverse EMT	69
miR-125	Downregulated	Trastuzumab	ERBB2, ERBB3	Reverse EMT	70
miR-200c	Downregulated	Trastuzumab	ZNF217, ZEB1	Inhibit TGF-β signaling	71
miR-27b	Downregulated	Tamoxifen	HMGB3	Promotes apoptosis	72
miR-124	Upregulated	Doxorubicin	STAT3	Resists the mechanism of cancer stem cells	73
miR-199b	Downregulated	Trastuzumab	HER2	Inhibits ERK1/2 and AKT pathways	74