Clinical trials with miR therapeutics.

MicroRNA name	Targeted miRNA	Mode of action	Background disease	Route of administration	Clinical trial number(s)	References
MRX34	miR-34a	miRNA mimic	Solid tumors	Intravenously/vehicle transfer (liposomal)	NCT01829971, NCT02862145	146
MesomiR 1d	miR-16	miRNA mimic	Malignant pleural mesothelioma, non-small cell lung cancer	Intravenously/vehicle transfer (non-living minicells)	NCT02369198	147
MRG-106 (cobomarsen)	miR-155	miRNA mimics	Adult T-cell leukaemia/lymphoma (ATLL)	Intravenously/vehicle	NCT03713320	148
INT-1B3	miR-193a-3p	miRNA mimics	Triple-negative breast cancer (TNBC), NSCLC, melanoma, colon cancer, and HCC	Intravenously/vehicle lipid nanoparticles	NCT04675996	149
TTX-MC138	miR-10b	miRNA inhibitor	Brain cancer, breast cancer	Dextran-coated iron oxide nanoparticles	NCT01849952	150