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Chemical modification of aminoglycosides by aminoglycoside-modifying enzymes. (A) An example of chemical modification of gentamicin catalyzed by aminoglycoside acetyltransferase AAC(3). (B) An example of chemical modification of amikacin catalyzed by aminoglycoside phosphotransferase APH(3′). (C) An example of chemical modification of kanamycin catalyzed by the aminoglycoside nucleotidyltransferase ANT(2″). ©Cold Spring Harbor Press (171), used with permission.
