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Semisynthetic aminoglycosides. (A) Kanamycin B scaffold with modification to dibekacin and subsequent modification to arbekacin. (B) Kanamycin A scaffold with modification to amikacin. (C) Gentamicin B scaffold with modification to isepamicin. (D) Sisomicin scaffold with modification to netilmicin and with modification to plazomicin. Green highlights indicate new chemical modifications; green circles indicate removal of hydroxyl groups.
