Table 1.
16S ribosomal RNA methyltransferase classesa
| Plasmidic 16S ribosomal RNA methyltransferase | Methylation Site | 4,6-DOS-linked aminoglycoside target(e.g., AMK, GEN, TOB, PLZ) | 4,5-DOS-linked aminoglycoside target(e.g., NEO) | Monosubstituted DOS-linked aminoglycoside target(e.g., APR) | No DOS ring(e.g., STR) |
|---|---|---|---|---|---|
| ArmA, RmtB, RmtB2, RmtC, RmtD1, RmtD2, RmtE, RmtF, RmtG, RmtH | N7 G1405 | Yesb | Noc | No | No |
| NpmA | N1 A1408 | Yes | Yes | Yes | No |
a
Abbreviations: DOS, 2-deoxystreptamine; AMK, amikacin; APR, apramycin; GEN, gentamicin; PLZ, plazomicin; STR, streptomycin; TOB, tobramycin.
b
No=16S rRNA methyltransferase does not methylate the respective aminoglycoside target and does not result in resistance.
c
Yes=16S rRNA methyltransferase methylates the respective aminoglycoside target, resulting in resistance.