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. 2016 May 23;7(1):10.1128/ecosalplus.ESP-0002-2016. doi: 10.1128/ecosalplus.esp-0002-2016

Figure 1.

Figure 1

Modular architecture of aminoacyl-tRNA synthetases and their partition in two classes with subclasses. Modularity in aaRS structure was first revealed after analysis of the E. coli AlaRS sequence (50) and was confirmed by crystallography of many other aaRSs (51). SepRS (O-phosphoseryl-tRNA synthetase) and PylRS (pyrrolysyl-tRNA synthetase) are noncanonical aaRSs found in Archaea, except a few bacterial PylRSs (see “The ambiguous status of archaeal aaRSs—a short synopsis,” below, for details).