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| Compounds | No competitor | Folic acid | |
|---|---|---|---|
| 20 µM | 100 µM | ||
| 4g | a41% | a81% | a96% |
| 20a | a45% | a88% | a98% |
| 20b | a36% | a77% | a91% |
| Trimethoprim | a6% | — | a99% |
Percentage survival is obtained by the formula = 100 − %AP, where %AP is the percent of growth inhibited by either the compound or positive control. Folate activity (through the action on DHFR and PTR1) was obtained with the compounds 20a, 20b, and 4g, along with a positive control trimethoprim.
