Skip to main content
. 2024 Oct 9;18(1):2402749. doi: 10.1080/19336950.2024.2402749

Figure 3.

A large figure. Panel A shows representative single-channel current traces of KcvNTS for all blockers used in this study. The slowing down of the block with increasing blocker size can be seen. Panels B-D show the respective single-channel IV curves, open probabilities, and average current for different blocker concentrations. The block is stronger at positive voltages in all cases.

Blocking properties of KcvNTS by cytosolic QAs. (a) Single-channel fluctuations in DPhPC bilayers in symmetric 100 mM KCl without and with different QAs recorded at +120 mV (upper traces) and −120 mV (lower traces). The closed channel is indicated by a dashed line. The blocker concentrations are given above the traces. (b) Apparent single-channel channel Iapp/V-relations without (black) and with (colored) blocker, concentrations indicated at the curves in either (b) or (c). (c) Apparent open probabilities and (d) time averaged Iavg/V relations with Iavg = Iapp·P0. Mean ± s.D., number of independent recordings is indicated in brackets.