Skip to main content
. 2024 Oct 9;18(1):2402749. doi: 10.1080/19336950.2024.2402749

Figure 9.

Panel A shows the on-rates kon for all blockers on both channels plotted over the membrane voltage. They all increase with positive voltages. There is no significant influence of blocker size. Panel B shows the off-rates koff for all blockers on both channels plotted over the membrane voltage. They all increase with negative voltages. There is a large decrease with increasing blocker size. Panels C and D plot the data points for +100 mV over the blocker size. There is no trend for kon, but koff is clearly decreased by increasing blocker size.

(a,b) Voltage dependence of the rate constants of open-state block (A) kon as calculated by Eq. 6 and (B) koff for different QAs. (c,d) Dependence of (C) kon and (D) koff at +100 mV on blocker diameter estimated by Robinson and Stokes [46]. Filled symbols: KcvNTS, open symbols: KcvS. Colors are defined in (A). Averages +/- sd of three experiments each.