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. 2024 Oct 9;18(1):2402749. doi: 10.1080/19336950.2024.2402749

Figure 10.

Panel A shows not ideal exponential fit of koff from an experiment in KcvNTS with TPrA. Panel B shows that the curve shape of koff plotted over the voltage is very similar in KcvNTS for different blockers. Panel C shows that also the shape of the KD plotted over the voltage is the same for all blockers.

(a) Exemplary fit of koff on an KcvNTS data set with 0.5 mM cytosolic TPrA with the equation koff = koff,0·exp(-zδ·FV/RT), zδ = 0.28, koff,0 = 1.05·105 s−1. (b) Overlay of the normalized (see text) koff for TPrA (dark blue), TBA (yellow), TPrA (orange) and THxA (light blue) in KcvNTS. §: No significant difference between the data points at this voltage. *: at least one data point is significantly different from the others. (c) Normalized (see text) KD of all blockers in KcvNTS. A significant difference for at least one of the data points from the others is only found at +40 mV. One-parameter ANOVA with threshold p = 0.05.