Supplementary Table 1.

Reported cases of Myasthenia Gravis (MG) with Morvan’s syndrome (MoS)

Author	Year of Publication	Number of Patients	Age/Gender	Initial Presentation	Duration From MG to MoS	Antibody Status	Thymus Status	Treatment	Outcome	Additional Comments
Briani et al.[8]	2010	1	40/M	Generalised MG followed by MoS	1 year	AchR and VGKC positive	Thymoma (B3)	IVIG with steroids	Death	MoS with recurrence of thymoma
Lee et al.[9]	1998	1	46/M	Generalised MG followed by MoS	1 year	AchR and VGKC positive	Non-invasive cortical thymoma (B2)	PE with steroids and azathioprine	Improved	Associated with atopic dermatitis and psoriasis
Nagappa et al.[7]	2017	1	54/M	MG followed by MoS	NS	NS	Thymectomy not done	NS	Death	NS
Weiss et al.	2012	1	22/M	Simultaneous	-	Both Positive	-	Steroids, IVIG and Rituximab	Improved	Associated with Kawasaki Disease
Anna Sadnika et al.	2010	1	76/M	Generalised MG followed by MoS	6 years	Both antibodies and anti-striational antibodies positive	Underwent thymectomy before MoS onset (Biopsy NA)	PE, IVIG, steroids and Rituximab	NS	Co-existent CIDP
Koge et al	2016	1	40/F	MG followed by MoS	1 year	Both positive	-	IVMP, PE and IVIG	Frequent relapses	complicated with MEFV gene mutations
Gwenolé Abgrall et al	2015	1	60/M	MG followed by MoS	8 years	Both positive	Thymoma	IVMP, PE and IVIG and Rituximab	Partially improved	Status dissociatus and disturbed dreaming
Huiqin Liu et al	2022	1	49/M	MG followed by MoS	1 year	Both positive with anti LGI-1, GABABR and titin positive	Thymoma	Steroids, IVIG and Rituximab	Improved	Associated nephrotic syndrome and cutaneous amyloidosis
Manera et al	2007	1	46/F	Simultaneous	-	Both and anti-MuSK positive	Thymic hyperplasia	prednisolone, IVIG, ciclosporin, and rituximab	Improved	-
Yasuo et al	1989	1	30/M	Simultaneous	-	NA	Thymoma	Steroids	Improved	-
Seong-il Oh et al	2022	1	67/M	Generalised MG followed by MoS	2 years	AchR positive and other anitbodies unavailable	Thymoma	Symptomatic treatment	Status quo	-
Masrori et al	2020	1	63/M	Ocular myasthenia followed by MoS	13 years	CASPR2 positive	Thymoma	Steroids, PE and azathioprine	Improved	-
Evoli et al.[10]	2002	4 NMT; 1 LE out of 207 patients with MG operated for thymoma	NA	MG followed by MoS	NA	VGKC negative	Thymoma	PE	Improved	MoS was transient and improved quickly.
Irani et al.[3]	2012	9	NA	NA	NA	CASPR2 and AChR positive in all	Thymoma in all patients with MoS and MG	PE, IVIG, IVMP	Outcome poor compared to those without thymoma	NS
Gastaldi et al.[4]	2019	5 NMT; 2/5 MoS	42.2* (3F, 2M)	MG	NA	AChR positive, CASPR, LGI, Netrin	Thymoma B2	Thymectomy, IST	2 MoS- 1 death, 1 remission	NS

*Mean age (33- 57 range). AchR: Acetylcholine receptor, CASPR -2: Anti-contactin-associated protein-like 2, CIDP: Chronic inflammatory demyelinating neuropathy, F: Female, IST- Immunosuppressive Therapy, IVMP: Intravenous Methylprednisolone, IVIG: Intravenous Immunoglobulin, LGI-1: Leucine rich glioma inactivated-1, LE: Limbic Encephalitis, M: Male, MoS: Morvan’s syndrome, MuSK: Muscle specific kinase, MG: Myasthenia Gravis, NMT: Neuromyotonia, NA: Not available, PE: Plasma exchange, VGKC: Voltage gated potassium channel, NS: Not specified