Table 2.
Univariate analysis for the clinical and pathological background of study patients categorized by the depth of cancer invasion.
| GC cases with SMD (n = 52) | GC cases with mucosal invasion (n = 150) | P-value | ||
|---|---|---|---|---|
| Age, years, median (min, max) | 73.0 (50.0, 93.0) | 75.0 (44.0, 90.0) | .64 | |
| Sex, n (%) | Female | 16 (30.8) | 41 (27.3) | .72 |
| Male | 36 (69.8) | 109 (72.7) | ||
| Atrophic gastritis, n (%) | Closed type | 6 (11.5) | 27 (18.0) | .38 |
| Open type | 46 (88.5) | 123 (82.0) | ||
| PMH of GC, n (%) | Yes | 7 (13.5) | 32 (21.3) | .31 |
| No | 45 (86.5) | 118 (78.7) | ||
| Period from HP eradication, n (%) | More than 10 years | 17 (32.7) | 27 (18.0) | .033 |
| <10 years | 35 (67.3) | 123 (82.0) | ||
| Last SI, years, median (IQR) | 3.0 (1.0, 5.0) | 1.0 (1.0, 2.0) | <.001 | |
| UML, n (%) | U | 10 (19.2) | 15 (10.0) | .17 |
| M | 21 (40.4) | 59 (39.3) | ||
| L | 21 (40.4) | 76 (50.7) | ||
| Size, mm, median (IQR) | 30 (17.3, 45.0) | 13 (7.0, 20.0) | <.001 | |
| Macroscopic type, n (%) | Type 0-I, 0-IIa (early-stage GC) | 4 (7.7) | 39 (26.0) | <.001 |
| Type 0-IIb, 0-IIc (early-stage GC) Type 1-5 (advanced-stage GC) |
28 (53.8) 20 (38.5) |
111 (74.0) 0 (0) |
||
| Pathology, n (%) | Diff. | 26 (50.0) | 139 (92.7) | <.001 |
| Mixed | 14 (26.9) | 6 (4.0) | ||
| Undiff. | 12 (23.1) | 5 (3.3) | ||
| Stage, n (%) | IA | 28 (53.8) | 150 (100.0) | <.001 |
| IB-IV | 24 (46.2) | 0 (0.0) | ||
| Treatment, n (%) | ESD | 22 (41.5) | 145 (96.7) | <.001 |
| Surgery or chemotherapy | 31 (58.5) | 5 (3.3) | ||
diff. = differentiated adenocarcinoma, ESD = endoscopic submucosal dissection, GC = gastric cancer, HP = Helicobacter pylori, IQR = interquartile range, L = lower third of the stomach, M = middle third of the stomach, PMH = past medical history, SMD = submucosal or deeper invasion, U = upper third of the stomach, undiff. = undifferentiated adenocarcinoma.