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. 2024 Nov 6;15:1467052. doi: 10.3389/fimmu.2024.1467052

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Copyright © 2024 Wang, Wang, Liu, Xu, Zhu, Zheng and Qi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of the HLMRGS and verification of its predictive ability in the TARGET database. (A) Volcano chart of 6286 DEGs between osteosarcoma and normal samples. (B) Venn diagram depicting the junction of HRGs, LRGs, and DEGs. (C, D) LASSO penalized Cox regression, and (E) multivariate Cox regression analyses of the DEHRGs and DELMRGs. (F) The association network diagram and types of 8 HLMRGs. (G) The risk scores, clinical outcomes, and expression of 8 modeled genes of osteosarcoma samples divided by median risk score. (H) KM survival analysis for the two risk cohorts. (I) The ROC curve of HLMRGS at 1, 3, 5 years.