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. 2024 Nov 6;15:1467052. doi: 10.3389/fimmu.2024.1467052

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Copyright © 2024 Wang, Wang, Liu, Xu, Zhu, Zheng and Qi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of immunotherapy response of the low- and high-risk groups in the TARGET database. (A) Box plot showing the expression variations in immune checkpoints between the two cohorts. (B) Multidimensional correlation plot illustrating the relationship of risk scores and the gene expression of immune checkpoints reaching statistically significant differences in both the TARGET and GSE21257 cohorts. (C) Expression divergences of MHC molecules of the two subgroups. (D) Heatmap illustrating the differences in the gene expression of chemokines, interleukins, interferons, receptors, and other cytokines between the two risk groups. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.