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. 2024 Nov 18;68(3):295–307. doi: 10.1042/EBC20240005

Figure 2. Regulation of NUAK1 by Calcium and Reactive Oxygen Species (ROS).

Figure 2

Activation of NUAK1 attenuates cytosolic PP1β complexes via phosphorylation of the regulatory MYPT1 subunit. This activity is required to enable efficient inhibition of GSK3β by AKT signalling downstream of ROS inactivation of PTEN, facilitating nuclear translocation of the anti-oxidant master transcription factor NRF2 (encoded by NFE2L2). Calcium and ROS also activate AMPK via CAMKK2. CAMKK2 contains a consensus ARK phosphosite that may be targeted by NUAK1.