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Along with AMPK, NUAKs share the ability to restrict mTORC1 activity via inhibitory phosphorylation of the mTORC1 subunit, RAPTOR. NUAK1 was recently shown to also regulate mTORC2 subcellular localisation to promote activation of a specific pool of AKT, upstream of FOXO1/3 but not of TSC1/2. The mechanism of mTORC2 regulation is unknown but may relate to NUAKs role in cytoskeletal regulation via PP1β/MYPT1.
