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. 2024 Nov 6;15:1396825. doi: 10.3389/fphar.2024.1396825

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Copyright © 2024 Fu, Xu, Zhang, Kang, Yang, Guo, Zhang, Zhou and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network pharmacology of the quality markers in GR after processing and their potential protein targets in major depressive disorder. (A) Overlap between proteins potentially targeted by 7 quality markers and those potentially associated with the disease. (B) Enrichment of the potential targets in the gene ontology biological processes (BPs, top), cellular compartments (CCs, middle), and molecular functions (MFs, bottom). (C) Enrichment of potential targets in the Kyoto encyclopedia of genes and genomes pathways. (D) Network of interactions among the quality markers and potential protein targets. (E) Quality markers showing the highest degrees of connectedness in the network in (D).