Figure 3.

Effects of shear stress on HMBEC miRNA profiles

(A) Heatmap representing expression levels of the most differentially expressed miRNAs between HBMEC^1.5 and HBMEC^static.

(B–S) The 18 most differentially expressed miRNAs in HBMEC^1.5 relative to HBMEC^static.

(T) Pathways most affected by shear stress in HBMEC^1.5 relative to HBMEC^static. Comparisons were performed using the differential expression function in CLC Genomics software V22. Data are represented as mean of normalized expression values. Statistical significance was calculated based on the FDR-adjusted p value (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 and ∗∗∗∗p < 0.0001).