Figure 5.

Effects of iRBC exposure on HMBEC miRNA profiles

(A) Heatmap showing differential miRNA expression levels between HBMEC^1.5+Rings and HBMEC^1.5+RBCs.

(B–I) The eight miRNAs most differentially expressed in HBMEC^1.5+Rings relative to HBMEC^1.5+RBCs.

(J) Target pathways most affected by exposure to iRBCs. Comparisons were performed using the differential expression function in CLC Genomics software V22. Data are represented as mean of normalized expression values. Statistical significance was calculated based on an FDR-adjusted p value (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 and ∗∗∗∗p < 0.0001).