Figure 7.

Effects of iRBC exposure on the electron transport chain in HMVEC-Ls

(A) Heatmap representing expression levels of the most differentially expressed miRNAs in HMVEC-L^1.5+Rings relative to HMVEC-L^1.5+RBCs.

(B–J) The nine miRNAs most significantly affected in HMVEC-L^1.5+Rings. Comparisons were performed using the differential expression function in CLC Genomics software V22. Data are represented as mean of normalized expression values. Statistical significance was calculated based on an FDR-adjusted p value (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 and ∗∗∗∗p < 0.0001).

(K) Genes encoding components of the electron transport chain were differentially expressed in HMVEC-L^1.5+Rings relative to HMVEC-L^1.5+RBCs, with most genes upregulated.