TABLE 3.
Characteristics of women who were referred for prenatal ES in each GLH.
| GLH 1 (n = 67) | GLH 2 (n = 49) | GLH 3 (n = 73) | GLH 4 (n = 23) | GLH 5 (n = 88) | GLH 6 (n = 49) | GLH 7 (n = 60) | Total (N = 409) | p-value | |
|---|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | ||
| Referral rate per 10,000 maternities | 11.9 | 4.3 | 13.5 | 7.1 | 10.2 | 7.2 | 9.3 | 8.6 | |
| Maternal age, years | |||||||||
| <25 | 9 (14.1) | 4 (8.2) | 6 (8.3) | 1 (4.5) | 10 (12.0) | 8 (17.4) | 12 (21.4) | 50 (12.8) | 0.35 |
| 25-<30 | 16 (25.0) | 9 (18.4) | 20 (27.8) | 3 (13.6) | 21 (25.3) | 15 (32.6) | 13 (23.2) | 97 (24.7) | |
| 30-<35 | 21 (32.8) | 22 (44.9) | 25 (34.7) | 9 (40.9) | 29 (34.9) | 14 (30.4) | 11 (19.6) | 131 (33.4) | |
| ≥35 | 18 (28.1) | 14 (28.6) | 21 (29.2) | 9 (40.9) | 23 (27.7) | 9 (19.6) | 20 (35.7) | 114 (29.1) | |
| Missing | 3 | 0 | 1 | 1 | 5 | 3 | 4 | 17 | |
| Maternal Ethnicity | |||||||||
| White | 29 (78.4) | 16 (61.5) | 34 (68.0) | 6 (100.0) | 49 (77.8) | 14 (60.9) | 33 (97.1) | 181 (75.7) | 0.007 |
| Black, Asian, and Other Minority | 8 (21.6) | 10 (38.5) | 16 (32.0) | 0 (0.0) | 14 (22.2) | 9 (39.1) | 1 (2.9) | 58 (24.3) | |
| Missing | 30 | 23 | 23 | 17 | 25 | 26 | 26 | 170 | |
| Index of Multiple Deprivation | |||||||||
| Quintile 1 (Most deprived) | 16 (26.2) | 13 (27.7) | 4 (6.0) | 1 (5.0) | 14 (20.3) | 20 (51.3) | 19 (37.3) | 87 (24.6) | <0.001 |
| Quintile 2 | 11 (18.0) | 16 (34.0) | 16 (23.9) | 3 (15.0) | 13 (18.8) | 6 (15.4) | 8 (15.7) | 73 (20.6) | |
| Quintile 3 | 9 (14.8) | 9 (19.1) | 23 (34.3) | 6 (30.0) | 13 (18.8) | 4 (10.3) | 9 (17.6) | 73 (20.6) | |
| Quintile 4 | 16 (26.2) | 4 (8.5) | 12 (17.9) | 6 (30.0) | 12 (17.4) | 6 (15.4) | 8 (15.7) | 64 (18.1) | |
| Quintile 5 (Least deprived) | 9 (14.8) | 5 (10.6) | 12 (17.9) | 4 (20.0) | 17 (24.6) | 3 (7.7) | 7 (13.7) | 57 (16.1) | |
| Missing | 6 | 2 | 6 | 3 | 19 | 10 | 9 | 55 | |
Note: Complex social factor variable not included because it was available only for women who proceeded with prenatal ES.
p-values from chi-square test.
Abbreviations: ES: exome sequencing, GLH: genomic laboratory hub.