TABLE 4.
Characteristics of women who proceeded with prenatal ES in each GLH.
| GLH 1 (n = 36) | GLH 2 (n = 22) | GLH 3 (n = 48) | GLH 4 (n = 11) | GLH 5 n = 63) | GLH 6 (n = 28) | GLH 7 (n = 33) | Total (N = 241) | p-value | |
|---|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | ||
| Maternal age, years | |||||||||
| <25 | 3 (8.3) | 3 (13.6) | 4 (8.3) | 1 (9.1) | 11 (17.5) | 4 (14.3) | 8 (24.2) | 34 (14.1) | 0.26 |
| 25-<30 | 9 (25.0) | 5 (22.7) | 10 (20.8) | 1 (9.1) | 14 (22.2) | 10 (35.7) | 8 (24.2) | 57 (23.7) | |
| 30-<35 | 15 (41.7) | 8 (36.4) | 21 (43.8) | 7 (63.6) | 18 (28.6) | 10 (35.7) | 4 (12.1) | 83 (34.4) | |
| ≥35 | 9 (25.0) | 6 (27.3) | 13 (27.1) | 2 (18.2) | 20 (31.7) | 4 (14.3) | 13 (39.4) | 67 (27.8) | |
| Maternal Ethnicity | |||||||||
| White | 23 (79.3) | 8 (42.1) | 36 (76.6) | 11 (100.0) | 47 (81.0) | 18 (64.3) | 25 (89.3) | 168 (76.4) | 0.002 |
| Black, Asian, and Other Minority | 6 (20.7) | 11 (57.9) | 11 (23.4) | 0 (0.0) | 11 (19.0) | 10 (35.7) | 3 (10.7) | 52 (23.6) | |
| Missing | 7 | 3 | 1 | 0 | 5 | 0 | 5 | 21 | |
| Index of Multiple Deprivation | |||||||||
| Quintile 1 (Most deprived) | 11 (32.4) | 6 (31.6) | 1 (2.1) | 0 (0.0) | 16 (25.8) | 14 (50.0) | 9 (29.0) | 57 (24.6) | 0.002 |
| Quintile 2 | 6 (17.6) | 8 (42.1) | 13 (27.7) | 2 (18.2) | 10 (16.1) | 8 (28.6) | 6 (19.4) | 53 (22.8) | |
| Quintile 3 | 4 (11.8) | 3 (15.8) | 15 (31.9) | 3 (27.3) | 9 (14.5) | 3 (10.7) | 8 (25.8) | 45 (19.4) | |
| Quintile 4 | 8 (23.5) | 1 (5.3) | 10 (21.3) | 3 (27.3) | 14 (22.6) | 2 (7.1) | 6 (19.4) | 44 (19.4) | |
| Quintile 5 (Least deprived) | 5 (14.7) | 1 (5.3) | 8 (17.0) | 3 (27.3) | 13 (21.0) | 1 (3.6) | 2 (6.5) | 33 (14.2) | |
| Missing | 2 | 3 | 1 | 0 | 1 | 0 | 2 | 9 | |
| Complex social factor indicator | |||||||||
| No | 26 (86.7) | 18 (90.0) | 44 (93.6) | 10 (90.9) | 56 (91.8) | 22 (78.6) | 25 (86.2) | 201 (88.9) | 0.53 |
| Yes | 4 (13.3) | 2 (10.0) | 3 (6.4) | 1 (9.1) | 5 (8.2) | 6 (21.4) | 4 (13.8) | 25 (11.1) | |
| Missing | 6 | 2 | 1 | 0 | 2 | 0 | 4 | 15 | |
Note: p-values from chi-square test except for complex social factor for which Fisher’s exact test was used.
Abbreviations: ES: exome sequencing, GLH: genomic laboratory hub.