Figure 1.

MRI-guided hippocampal TMS targeting strategies. Two targeting strategies were proposed to identify superficial stimulation sites within the left lateral parietal cortex (LLPC). Strategy 1—FC-guided voxel-based approach using seed-based connectivity analysis to identify stimulation sites based on rsfMRI seed-to-voxel connectivity map, centering from the left hippocampal body. Strategy 2—SC-guided voxel-based approach using voxel-wise probability tractography to generate a probability map of tracts extending from the hippocampal body to the cortical surface. For both strategies, we employed a parietal-constrained mask to locate the target within the parietal lobe. After clustering and thresholding, the cluster with the highest center of gravity within each map was chosen as the optimal stimulation site for that strategy.