Figure 1.

Magnetic particle imaging (MPI) shows in vivo pharmacokinetics of iron oxide nanoparticles to sentinel lymph nodes (SLN) of C57 immunocompetent mice. MPI was acquired preinjection to assess mouse background signal then at 3 timepoints following intradermal injection of VivoTrax to the (A) left hindpaw, (B) right base of tail, (C) left forepaw, and (D) tongue. Arrows indicate location of injection sites. Sentinel lymph nodes are outlined by squares, including the (A) ipsilateral popliteal lymph node, (B) inguinal lymph node, (C) axillary lymph node, and (D) cervical lymph node(s), respectively. Absolute quantification of iron at each lymph node is indicated. A, B, and D are coronal views, whereas imaging of the forepaw required positioning the mouse on its side, resulting in a sagittal view.