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. 2024 Oct 25;1(3):umae024. doi: 10.1093/radadv/umae024

Figure 4.

Figure 4.

Assessment of preclinical magnetic particle imaging (MPI) technical specifications for sentinel lymph node imaging. (A) Sensitivity and linearity MPI phantom. Three-dimensional MPI of 10 vials with Fe quantities of 25, 50, 75, 100, 150, 200, 300, 400, 600, 800 ng in 7 µL, displayed with window/level = 1/0.5 au. The white dotted line represents the position of the 25-ng VivoTrax sample, which did not meet MPI detection criteria. The limit of detection was determined as 50 ng. Line profiles drawn through MPI signal peaks show signal intensities of each sample and integrated MPI signal is directly linear with Fe quantity (R2 = 0.99). (B) Shine-through/resolution MPI phantom. Three-dimensional MPI of a center vial containing 13.5 µg Fe and satellite vials of 675 ng are 2.5 mm to 20 mm from the source (well center-to-center distance). Phantom wells were 1.5 mm in diameter. MPI is displayed with window/level = 8/4 au. Line plots through MPI signals show that a 675-ng sample can be resolved at 3.5 mm edge-to-edge distance from center vial (5 mm center-to-center distance). Red asterisk (*) indicates the limit of detection (A) and the limit of resolution (B).