Figure 5.

Proposed clinical all-magnetic sentinel lymph node biopsy (SLNB) workflow. (A) First, an iron oxide nanoparticle tracer is administered adjacent to a tumor. (B) A magnetic particle imaging (MPI) scan is acquired before surgery to identify the location and number of SLNs draining from a primary tumor. Provided the data from this study, this image could be acquired hours to days after iron injection, which provides tremendous clinical flexibility. (C) As currently practiced, the surgery could be guided by a magnetometer in real time and (D) excised SLNs would be sent for pathology and staging.